Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome
- PMID: 21249756
- Bookshelf ID: NBK7029
Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome
Copyright © 2009-, Douglas L Riegert-Johnson.
Sections
- Introduction and Background
- Epidemiology
- Historical background
- Pathophysiology
-
The
CDKN1B gene/p27 protein and a MEN1-like condition (MENX) - MEN1 follows the Two-Hit Model
- MEN1 mutations in multiple endocrine neoplasia patients
- Menin: the MEN1 protein
- Clinical Genetics
- Natural History
- Diagnosis
- Genetic diagnosis
- Cancer surveillance and management protocols
- Management
- Acknowledgements
- References
References
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- Gibril F, Schumann M, Pace A, Jensen RT. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore) 2004;83(1):43–83. Erratum in: Medicine (Baltimore) 2004; 83(3): 175. - PubMed
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- Burgess JR, Harle RA, Tucker P, Parameswaran V, Davies P, Greenaway TM, Shepherd JJ. Adrenal lesions in a large kindred with multiple endocrine neoplasia type 1. Arch Surg. 1996;131(7):699–702. - PubMed
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- Skogseid B, Larsson C, Lindgren PG, Kvanta E, Rastad J, Theodorsson E, Wide L, Wilander E, Oberg K. Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 1992;75(1):76–81. - PubMed
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- Debelenko LV, Brambilla E, Agarwal SK, Swalwell JI, Kester MB, Lubensky IA, Zhuang Z, Guru SC, Manickam P, Olufemi SE, Chandrasekharappa SC, Crabtree JS, Kim YS, Heppner C, Burns AL, Spiegel AM, Marx SJ, Liotta LA, Collins FS, Travis WD, Emmert-Buck MR. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Mol Genet. 1997;6(13):2285–2290. - PubMed
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- Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA, Jensen RT, Liotta LA, Lubensky IA. The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology. 1997;113(3):773–781. - PubMed
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