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Review

Pharmacokinetic implications of resistance

Marta Boffito
Anna Maria Geretti
, editors.
In: Antiretroviral Resistance in Clinical Practice. London: Mediscript; 2006. Chapter 8.
Free Books & Documents
Review

Pharmacokinetic implications of resistance

Marta Boffito.
Free Books & Documents

Excerpt

Pharmacokinetics is the study of the bodily absorption, distribution, metabolism and excretion of drugs. The use of multidrug antiretroviral therapy for HIV-1-infected patients, and the need for these patients to receive multiple concomitant drugs for either the treatment of opportunistic infections or the management of drug-related adverse events, makes it imperative to understand the pharmacokinetics of all the drugs in the regimen. In addition, variability in the response to potent antiretroviral regimens is common as a result of multiple factors, including adherence, viral resistance, host immunology and drug pharmacology [1,2]. Inter-patient variability in drug absorption, distribution, metabolism and excretion can all contribute to variability in plasma drug concentrations [1,2].

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References

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