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Comment
. 2011 Jan 18;19(1):3-4.
doi: 10.1016/j.ccr.2011.01.004.

Hard times for oncogenic BRAF-expressing melanoma cells

Miles D Houslay  1
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Hard times for oncogenic BRAF-expressing melanoma cells

Miles D Houslay. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Arozarena et al. describe that the oncogenic BRAF Val600Glu mutant, which occurs in about half of melanomas, downregulates the cGMP-hydrolysing phosphodiesterase PDE5A in melanoma cells through the ERK-MAPK cascade coupled to the POU-domain transcription factor BRN2, thereby increasing intracellular cGMP levels and promoting invasiveness.

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