Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice
- PMID: 21251609
- PMCID: PMC6038118
- DOI: 10.1016/j.ccr.2011.01.006
Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice
Abstract
The cell of origin for basal cell carcinoma (BCC) remains controversial. In this issue of Cancer Cell, Wang et al. provide strong evidence that BCC arise from hair follicle stem cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
-
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.Cancer Cell. 2011 Jan 18;19(1):114-24. doi: 10.1016/j.ccr.2010.11.007. Epub 2011 Jan 6. Cancer Cell. 2011. PMID: 21215705 Free PMC article.
References
-
- Cotsarelis G, Sun TT, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell. 1990;61:1329–1337. - PubMed
-
- Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui CC, Dlugosz AA. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet. 2000;24:216–217. - PubMed
-
- Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, Cotsarelis G. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med. 2005;11:1351–1354. - PubMed
-
- Jih D, Lyle S, Elenitsas R, Elder D, Cotsarelis G. Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells. J Cutan Pathol. 1999;26:113–118. - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
