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Comment
. 2011 Jan 18;19(1):6-8.
doi: 10.1016/j.ccr.2011.01.003.

Metastatic colon cancer cells negotiate the intravasation Notch

Gerhard Christofori  1
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Metastatic colon cancer cells negotiate the intravasation Notch

Gerhard Christofori. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.

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