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Comment
. 2011 Jan 18;19(1):9-10.
doi: 10.1016/j.ccr.2011.01.007.

Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye

Ravindra Majeti  1 , Irving L Weissman
Affiliations
Comment

Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye

Ravindra Majeti et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Goardon et al. revise earlier conclusions regarding acute myelogenous leukemia (AML) stem cells by demonstrating that in the majority of patients, they reside in two hierarchically related populations most similar to normal hematopoietic progenitors. These findings have implications for therapeutic targeting of these cells.

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Comment on

  • Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.
    Goardon N, Marchi E, Atzberger A, Quek L, Schuh A, Soneji S, Woll P, Mead A, Alford KA, Rout R, Chaudhury S, Gilkes A, Knapper S, Beldjord K, Begum S, Rose S, Geddes N, Griffiths M, Standen G, Sternberg A, Cavenagh J, Hunter H, Bowen D, Killick S, Robinson L, Price A, Macintyre E, Virgo P, Burnett A, Craddock C, Enver T, Jacobsen SE, Porcher C, Vyas P. Goardon N, et al. Cancer Cell. 2011 Jan 18;19(1):138-52. doi: 10.1016/j.ccr.2010.12.012. Cancer Cell. 2011. PMID: 21251617

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