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Review
. 2011 Apr;31(4):728-33.
doi: 10.1161/ATVBAHA.109.200964. Epub 2011 Jan 20.

Tissue factor-bearing microparticles and thrombus formation

Jeffrey I Zwicker  1 , Cameron C Trenor 3rd, Barbara C Furie, Bruce Furie
Affiliations
Review

Tissue factor-bearing microparticles and thrombus formation

Jeffrey I Zwicker et al. Arterioscler Thromb Vasc Biol. 2011 Apr.

Abstract

Blood microparticles are vesicular structures with a diameter of 100 to 1000 nm that are present in the blood of normal subjects and in patients with various diseases. These microparticles are derived from cells that circulate in the blood and cells associated with the blood vessel wall. Microparticle membranes retain the protein receptors of their parent cells and may retain RNAs and other cytosolic content. On the basis of surface protein expression, microparticles are known to be derived from platelets, granulocytes, monocytes, endothelial cells, smooth muscle cells, and tumor cells. Only a subpopulation of these microparticles expresses tissue factor.

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References

    1. Spicer EK, Horton R, Bloem L, Bach R, Williams KR, Guha A, Kraus J, Lin TC, Nemerson Y, Konigsberg WH. Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. Proc Natl Acad Sci U S A. 1987;84:5148–5152. - PMC - PubMed
    1. Morrissey JH, Fakhrai H, Edgington TS. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell. 1987;50:129–135. - PubMed
    1. Bach R, Konigsberg WH, Nemerson Y. Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. Biochemistry. 1988;27:4227–4231. - PubMed
    1. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359:938–949. - PubMed
    1. Harlos K, Martin DM, O’Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW. Crystal structure of the extracellular region of human tissue factor. Nature. 1994;370:662–666. - PubMed