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Case Reports
. 2011 Feb;117(2 Pt 2):473-476.
doi: 10.1097/AOG.0b013e3181fd29ae.

Severe hypercalcemia associated with uterine leiomyoma in pregnancy

Edward Tarnawa  1 , Scott Sullivan, Paul Underwood, Mary Richardson, Laura Spruill
Affiliations
Case Reports

Severe hypercalcemia associated with uterine leiomyoma in pregnancy

Edward Tarnawa et al. Obstet Gynecol. 2011 Feb.

Abstract

Background: Uterine leiomyomas are the most common pelvic tumor, and a frequent indication of the need for gynecologic surgery. Although usually asymptomatic, life-threatening cases can occur. We present a case of critical hypercalcemia associated with a leiomyoma during pregnancy with the intention of highlighting the endocrinology of leiomyomas, features shared with malignant neoplasms, and the potential for effects on obstetric outcomes.

Case: A 32-year-old gravid woman with a large leiomyoma presented at 33 5/7 weeks of gestation with critical hypercalcemia requiring intensive care. Postpartum myomectomy cured her hypercalcemia, which was driven by parathyroid hormone-related protein (PTHrP) produced by the tumor.

Conclusion: Obstetricians should be aware of the existence of humoral hypercalcemia related to leiomyomas and the potential effects on pregnancy.

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References

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