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Review
. 2011 Feb;12(2):79-89.
doi: 10.1038/nrm3043.

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

Chris Jopling  1 , Stephanie Boue, Juan Carlos Izpisua Belmonte
Affiliations
Review

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

Chris Jopling et al. Nat Rev Mol Cell Biol. 2011 Feb.

Abstract

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.

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