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. 1988 Nov:34:2389-93.

An antihistamine decongestant in the prevention of acute otitis media in children with colds

R Brownoff, L J Hutchison

An antihistamine decongestant in the prevention of acute otitis media in children with colds

R Brownoff et al. Can Fam Physician. 1988 Nov.

Abstract

Most clinical drug trials relating to acute otitis media have evaluated medications in terms of treatment. In this randomized double-blind, cross-over study, the effectiveness of an antihistamine decongestant in the prevention of AOM was investigated, rather than the treatment. The medication/placebo was started at the onset of a cold and continued throughout its duration. No treatment effect was evident in the results obtained with 308 children who completed the eight-month study. However, the results indicated a strong relationship between colds and AOM, and a trend toward higher occurrence of AOM in children under four years of age.

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