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. 2010:2010:248157.
doi: 10.1155/2010/248157. Epub 2010 Dec 30.

Xenobiotic exposure and autoimmune hepatitis

Kathleen M Gilbert  1
Affiliations

Xenobiotic exposure and autoimmune hepatitis

Kathleen M Gilbert. Hepat Res Treat. 2010.

Abstract

Although genetics contributes to the development of autoimmune diseases, it is clear that "environmental" factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis.

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Figures

Figure 1
Figure 1
Oxidative metabolism of TCE.
Figure 2
Figure 2
Model of TCE-induced AIH.
See this image and copyright information in PMC

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