doi: 10.1007/BF01625726.
Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation
Affiliations
- PMID: 2125385
- DOI: 10.1007/BF01625726
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Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation
Virchows Arch A Pathol Anat Histopathol.
1990.
Abstract
The effect of a tumour angiogenesis factor on proliferation of various kinds of cells was examined in vitro. The factor (TAF) a polypeptide of 14000 molecular weight, was extracted and purified from the conditioned medium of ovarian clear cell carcinoma cell line (HUOCA-II). TAF at concentrations of 10 ng/ml and 100 ng/ml promoted proliferation of the endothelial cells and induced tube formation. However, it had no stimulatory effect on the proliferation of fibroblasts, endometrial columnar cells, squamous epithelial cells or cancer cells.
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