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. 1990;417(6):473-6.
doi: 10.1007/BF01625726.

Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation

I Ishiwata  1 , C Ishiwata, M Soma, D R Naik, H Hashimoto, T Sudo, H Ishikawa
Affiliations

Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation

I Ishiwata et al. Virchows Arch A Pathol Anat Histopathol. 1990.

Abstract

The effect of a tumour angiogenesis factor on proliferation of various kinds of cells was examined in vitro. The factor (TAF) a polypeptide of 14000 molecular weight, was extracted and purified from the conditioned medium of ovarian clear cell carcinoma cell line (HUOCA-II). TAF at concentrations of 10 ng/ml and 100 ng/ml promoted proliferation of the endothelial cells and induced tube formation. However, it had no stimulatory effect on the proliferation of fibroblasts, endometrial columnar cells, squamous epithelial cells or cancer cells.

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