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Meta-Analysis
. 2011 Apr;204(4):340.e1-12.
doi: 10.1016/j.ajog.2010.11.013. Epub 2011 Jan 22.

Effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses

Katy Gouin  1 , Kellie Murphy, Prakesh S Shah; Knowledge Synthesis group on Determinants of Low Birth Weight and Preterm Births
Collaborators, Affiliations
Meta-Analysis

Effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses

Katy Gouin et al. Am J Obstet Gynecol. 2011 Apr.

Abstract

Objective: To review systematically maternal antenatal cocaine exposure and adverse perinatal outcomes.

Study design: Medline, Embase, CINAHL and secondary references in relevant studies were searched. English language studies of antenatal cocaine exposure and pregnancy outcomes published from 1966 to July 2009 were included. Metaanalyses were performed using the random effects model.

Results: Thirty-one studies were included. Cocaine use during pregnancy was associated with significantly higher odds of preterm birth (odds ratio [OR], 3.38; 95% confidence interval [CI], 2.72-4.21), low birthweight (OR, 3.66; 95% CI, 2.90-4.63), and small for gestational age infants (OR, 3.23; 95% CI, 2.43-4.30), as well as shorter gestational age at delivery (-1.47 week; 95% CI, -1.97 to -0.98 week) and reduced birthweight (-492 g; 95% CI, -562 to -421 g).

Conclusion: Prenatal cocaine exposure is significantly associated with preterm birth, low birthweight, and small for gestational age infants.

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