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. 2011 Mar 1;203(5):595-601.
doi: 10.1093/infdis/jiq098. Epub 2011 Jan 21.

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C

Jacob Nattermann  1 , Martin Vogel, Hans Dieter Nischalke, Mark Danta, Stefan Mauss, Hans-Jörg Stellbrink, Axel Baumgarten, Christoph Mayr, Raffaele Bruno, Cristina Tural, Gerd Klausen, Bonaventura Clotet, Uwe Naumann, Thomas Lutz, Michael Rausch, Knud Schewe, Bernhard Bienek, Georg Haerter, Tilman Sauerbruch, Juergen K Rockstroh, Ulrich Spengler
Affiliations

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C

Jacob Nattermann et al. J Infect Dis. .

Abstract

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.

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References

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