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. 2009 Jan 1:3:61-67.
doi: 10.1115/DETC2009-86425.

DESIGN AND PRELIMINARY VALIDATION OF A RAPID AUTOMATED BIODOSIMETRY TOOL FOR HIGH THROUGPUT RADIOLOGICAL TRIAGE

Youhua Chen  1 , Jian Zhang, Hongliang Wang, Guy Garty, Yanping Xu, Oleksandra V Lyulko, Helen C Turner, Gerhard Randers-Pehrson, Nabil Simaan, Y Lawrence Yao, D J Brenner
Affiliations

DESIGN AND PRELIMINARY VALIDATION OF A RAPID AUTOMATED BIODOSIMETRY TOOL FOR HIGH THROUGPUT RADIOLOGICAL TRIAGE

Youhua Chen et al. Proc ASME Des Eng Tech Conf. .

Abstract

This paper presents design, hardware, software, and parameter optimization for a novel robotic automation system. RABiT is a Rapid Automated Biodosimetry Tool for high throughput radiological triage. The design considerations guiding the hardware and software architecture are presented with focus on methods of communication, ease of implementation, and need for real-time control versus soft time control cycles. The design and parameter determination for a non-contact PVC capillary laser cutting system is presented. A novel approach for lymphocyte concentration estimation based on computer vision is reported. Experimental evaluations of the system components validate the success of our prototype system in achieving a throughput of 6,000 samples in a period of 18 hours.

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Figures

Figure 1
Figure 1
System breadboard prototype.
Figure 2
Figure 2
Lymphocyte separation of blood sample sequence.
Figure 3
Figure 3
Hardware architecture.
Figure 4
Figure 4
Centrifuge tube balancing position and electronic components.
Figure 5
Figure 5
Multi-purpose material handling gripper.
Figure 6
Figure 6
Cell harvesting module.
Figure 7
Figure 7
Barcode on the capillary.
Figure 8
Figure 8
(a), (b) Cross-section views of capillary cut at 0.8W and 30rpm; (c), (d): 0.8W and 40rpm and (e), (f): 0.8W and 50rpm.
Figure 9
Figure 9
Lymphocyte calibration of light absorption.
Figure 10
Figure 10
Imaging module prototype with two cameras for imaging DAPI and cell mask orange.
Figure 11
Figure 11
Observed aspect ratio.
Figure 12
Figure 12
Sample image analysis
Figure 13
Figure 13
Radiation exposure dose calibration
See this image and copyright information in PMC

References

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