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. 2012 Feb;35(1):89-97.
doi: 10.1007/s10753-011-9293-9.

Inhibitory effects of prior low-dose X-irradiation on cold-induced brain injury in mouse

Masaaki Yoshimoto  1 , Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka
Affiliations

Inhibitory effects of prior low-dose X-irradiation on cold-induced brain injury in mouse

Masaaki Yoshimoto et al. Inflammation. 2012 Feb.

Abstract

We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.

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