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. 1990 Dec;81(12):1191-4.
doi: 10.1111/j.1349-7006.1990.tb02675.x.

X protein of hepatitis B virus resembles a serine protease inhibitor

S Takada  1 , K Koike
Affiliations

X protein of hepatitis B virus resembles a serine protease inhibitor

S Takada et al. Jpn J Cancer Res. 1990 Dec.

Abstract

The X protein of hepatitis B virus (HBV) has been shown to be a trans-activator for viral and cellular genes. Amino acid sequences in X protein were found to be highly homologous to functionally essential sequences in the "Kunitz domain," characteristic of Kunitz-type serine protease inhibitors. Mutations at these sequences completely abolished trans-activation. Consequently, HBV X protein resembles a serine protease inhibitor or its analogue, and may bring about trans-activation by activating certain transcriptional factors through proteolytic cleavage alteration.

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References

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