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. 2011 Apr;72(4):312-8.
doi: 10.1016/j.humimm.2011.01.003. Epub 2011 Jan 21.

The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans

Aleksandr Lazaryan  1 , Wei Song, Elena Lobashevsky, Jianming Tang, Sadeep Shrestha, Kui Zhang, Janet M McNicholl, Lytt I Gardner, Craig M Wilson, Robert S Klein, Anne Rompalo, Kenneth Mayer, Jack Sobel, Richard A Kaslow; HIV Epidemiology Research Study Group; Reaching for Excellence in Adolescent Care and Health Study Group
Collaborators, Affiliations

The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans

Aleksandr Lazaryan et al. Hum Immunol. 2011 Apr.

Abstract

Populations of African ancestry continue to account for a disproportionate burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. We investigated the effects of human leukocyte antigen (HLA) class I markers in association with virologic and immunologic control of HIV-1 infection among 338 HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4(+) T cells were examined both separately and combined to represent 3 categories of HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were associated with 1 or more of the endpoints in univariate analyses. After multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 progression, the subset of alleles more strongly or consistently associated with HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. Carriage of infrequent HLA-B but not HLA-A alleles was associated with more favorable disease outcomes. Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries.

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Figures

Figure 1
Figure 1
Distribution of continuous clinical outcomes among African Americans from REACH (1996-1998) and HER (1993-2000) study cohorts. KS, Kolmogorov-Smirnov test for normality.
Figure 2
Figure 2
Carriage of frequent and infrequent HLA-B alleles among HIV-1 control groups. Proportion of subjects carrying at least one infrequent allele differs significantly across the three incremental disease control groups (P = 0.028).
See this image and copyright information in PMC

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