Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Jan 27;69(2):183-5.
doi: 10.1016/j.neuron.2011.01.007.

Controlled demolition: Smurf1 regulates neuronal polarity by substrate switching

Michael Stiess  1 , Frank Bradke
Affiliations
Free article
Comment

Controlled demolition: Smurf1 regulates neuronal polarity by substrate switching

Michael Stiess et al. Neuron. .
Free article

Abstract

During axon specification, growth promoting proteins localize selectively to the growing axon. In this issue of Neuron, Cheng et al. report how selective protein degradation, controlled by a substrate switch of the ubiquitin ligase Smurf1, specifies Par6 and RhoA localization and thereby regulates neuronal polarity.

PubMed Disclaimer

Comment on

LinkOut - more resources