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. 2011 Apr;55(4):1771-3.
doi: 10.1128/AAC.01045-10. Epub 2011 Jan 24.

In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine

Alex van Belkum  1 , Ahmed H Fahal, Wendy W J van de Sande
Affiliations

In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine

Alex van Belkum et al. Antimicrob Agents Chemother. 2011 Apr.

Abstract

Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains were determined. It appeared that posaconazole was highly active against M. mycetomatis but terbinafine was only moderately active. Since posaconazole has an excellent safety profile, it might provide an important alternative in mycetoma therapy.

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Figures

FIG. 1.
FIG. 1.
Antifungal susceptibilities (expressed as MICs) of 34 M. mycetomatis isolates to ketoconazole (KTZ), itraconazole (ITZ), posaconazole (PCZ), and terbinafine (TBF) according to the XTT assay.
See this image and copyright information in PMC

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