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Review
. 1990 Aug;72(8):599-608.
doi: 10.1016/0300-9084(90)90123-x.

Antithrombin III: structural and functional aspects

L Mourey  1 , J P Samama, M Delarue, J Choay, J C Lormeau, M Petitou, D Moras
Affiliations
Review

Antithrombin III: structural and functional aspects

L Mourey et al. Biochimie. 1990 Aug.

Abstract

Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.

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