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. 2011 Apr;26(4):933-40.
doi: 10.1093/humrep/deq333. Epub 2011 Jan 25.

Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment?

Y Hong  1 , Y-W Zhou, J Tao, S-X Wang, X-M Zhao
Affiliations

Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment?

Y Hong et al. Hum Reprod. 2011 Apr.

Abstract

BACKGROUND The aim of this study was to investigate the effect of chromosomal polymorphic variations on the outcome of IVF and embryo transfer (IVF-embryo transfer) treatment for infertile couples. METHODS During the period from October 2006 to December 2009, 1978 infertile couples who had received their first IVF-embryo transfer treatment cycle in our hospital were selected for this retrospective study, and the frequency of chromosomal polymorphic variations was calculated. From these, 1671 couples were selected and divided into three groups: 1402 couples with normal chromosomes (Group 1/control group), 82 couples with chromosomal polymorphic variations in only females (Group 2) and 187 couples with chromosomal polymorphic variations in only males (Group 3). The clinical pregnancy rates (CPR), early miscarriage rates and ongoing pregnancy rates after IVF-embryo transfer treatment were compared. RESULTS There were no statistically significant differences among the three groups in implantation rates (29.37% in the control group, 29.70% in Group 2 and 31.41% in Group 3, P > 0.05) and CPR (45.86, 46.34 and 51.87%, respectively, P > 0.05). Although there was a trend toward higher first trimester pregnancy loss rates in Group 3 (male chromosomal polymorphic variations), but not in Group 2, compared with normal karyotype couples (10.31 versus 6.84%), the difference did not reach significance (P > 0.05). CONCLUSIONS Chromosomal polymorphic variations appear to have no adverse effects on the outcome of IVF-embryo transfer treatment.

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References

    1. Antonelli A, Gandini L, Petrinelli P, Marcucci L, Elli R, Lombardo F, Dondero F, Lenzi A. Chromosomal alterations and male infertility. J Endocrinol Invest. 2000;23:677–683. - PubMed
    1. Bhasin MK. Human population cytogenetics: a review. Int J Hum Genet. 2005;5:83–152.
    1. Broccoli D. Function, replication and structure of the mammalian telomere. Cytotechnology. 2004;45:3–12. doi:10.1007/s10616-004-5120-6. - DOI - PMC - PubMed
    1. Carp HJA. Recurrent miscarriage: genetic factors and assessment of the embryo. Isr Med Assoc J. 2008;10:229–231. - PubMed
    1. Choi JM, Chung P, Veeck L, Mielnik A, Palermo GD, Schlegel PN. AZF microdeletions of the Y chromosome and in vitro fertilization outcome. Fertil Steril. 2004;81:337–341. doi:10.1016/j.fertnstert.2003.06.030. - DOI - PubMed

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