Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Jan 18;9(1):e1001008.
doi: 10.1371/journal.pbio.1001008.

The importance of synthetic associations will only be resolved empirically

David B Goldstein  1
Affiliations
Comment

The importance of synthetic associations will only be resolved empirically

David B Goldstein. PLoS Biol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has declared that no competing interests exist.

Comment on

References

    1. Pritchard J. K. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet. 2001;69:124–137. - PMC - PubMed
    1. Reich D. E, Lander E. S. On the allelic spectrum of human disease. Trends Genet. 2001;17:502–510. - PubMed
    1. Manolio T. A, Collins F. S, Cox N. J, Goldstein D. B, Hindorff L. A, et al. Finding the missing heritability of complex diseases. Nature. 2009;461:747–753. - PMC - PubMed
    1. Merikangas A. K, Corvin A. P, Gallagher L. Copy-number variants in neurodevelopmental disorders: promises and challenges. Trends Genet. 2009;25:536–544. - PubMed
    1. Dickson S. P, Wang K, Krantz I, Hakonarson H, Goldstein D. B. Rare variants create synthetic genome-wide associations. PLoS Biol. 2010;8:e1000294. doi: 10.1371/journal.pbio.1000294. - DOI - PMC - PubMed