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Clinical Trial
. 1990 Dec 20;37(6):971-5.
doi: 10.1016/0960-0760(90)90452-q.

Comparison of the effects of high dose Estramustine phosphate and mitomycin C on the time to progression and length of survival of patients with progressive, advanced endocrine-independent prostatic cancer: an interim analysis of EORTC-GU Group study no. 30865

D W Newling  1 , S Fossa, U Tunn, K H Kurth, M De Pauw, R Sylvester
Affiliations
Clinical Trial

Comparison of the effects of high dose Estramustine phosphate and mitomycin C on the time to progression and length of survival of patients with progressive, advanced endocrine-independent prostatic cancer: an interim analysis of EORTC-GU Group study no. 30865

D W Newling et al. J Steroid Biochem Mol Biol. .

Abstract

Patients with hormone escaped advanced progressive prostate cancer were randomized either to receive either high-dose Estramustine phosphate orally or Mitomycin C by i.v. injection every 6 weeks until signs of progression or death supervened. Patients on both arms progressed rapidly, with a median time to progression of 5 months and a median length of survival of only 10 months. Toxicity was very considerable in both arms.

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