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. 2011 Feb;70(2):108-13.
doi: 10.1007/s00393-010-0687-0.

[Methotrexate toxicity. Myths and facts]

[Article in German]
G Keysser  1
Affiliations

[Methotrexate toxicity. Myths and facts]

[Article in German]
G Keysser. Z Rheumatol. 2011 Feb.

Abstract

Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying antirheumatic drugs. In addition, a mutagenic potential could not be demonstrated even after long-term application. Therefore, MTX will maintain its significant role in antirheumatic therapy also in the near future.

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