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. 2011 Jun 30;95(8):2690-2.
doi: 10.1016/j.fertnstert.2010.12.034. Epub 2011 Jan 26.

Endometrial polyps affect uterine receptivity

Beth W Rackow  1 , Elisa Jorgensen, Hugh S Taylor
Affiliations

Endometrial polyps affect uterine receptivity

Beth W Rackow et al. Fertil Steril. .

Abstract

This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.

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Figures

Figure 1
Figure 1
(A) Endometrial HOXA10 gene expression in control and polyp groups; (B) Endometrial HOXA11 gene expression in control and polyp groups.
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