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. 2011 Feb;34(2):403-5.
doi: 10.2337/dc10-1100.

HbA1c in nondiabetic Dutch infants aged 8-12 months: the GECKO-Drenthe birth cohort study

Hanneke Jansen  1 , Haika G Huiting, Salome Scholtens, Pieter J J Sauer, Ronald P Stolk
Affiliations

HbA1c in nondiabetic Dutch infants aged 8-12 months: the GECKO-Drenthe birth cohort study

Hanneke Jansen et al. Diabetes Care. 2011 Feb.

Abstract

Objective: An international committee of experts recommended using HbA(1c) for diagnostic testing for diabetes. Little is known about normal values of HbA(1c) in infants. The aim of this study is to describe the distribution of HbA(1c) in 8- to 12-month-old nondiabetic infants.

Research design and methods: HbA(1c) was measured in 86 infants participating in the Groningen Expert Center for Kids with Obesity (GECKO)-Drenthe birth cohort study. Anthropometric measurements were performed at Well Baby Clinics. Data on parents and children were collected prospectively using questionnaires.

Results: HbA(1c) was normally distributed with a mean (SD) HbA(1c) level of 5.38% (0.24), range 4.8-6.0% or 35.29 mmol/mol (2.65), range 29.1-42.1 mmol/mol. Age, sex, birth weight, duration of breastfeeding, anthropometric measurements, and maternal BMI were not associated with HbA(1c).

Conclusions: We found a normal distribution of HbA(1c) with a relatively high mean HbA(1c) of 5.38%. No significant association between risk factors for type 2 diabetes and HbA(1c) levels was found.

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Figures

Figure 1
Figure 1
Distribution of HbA1c in infants aged 8–12 months. Mean (SD): 5.38% (0.24) or 35.29 mmol/mol (2.65).
See this image and copyright information in PMC

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