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. 2011 Mar;89(3):460-3.
doi: 10.1038/clpt.2010.254. Epub 2011 Jan 26.

Early human screening of medications to treat drug addiction: novel paradigms and the relevance of pharmacogenetics

K A Perkins  1 , C Lerman
Affiliations

Early human screening of medications to treat drug addiction: novel paradigms and the relevance of pharmacogenetics

K A Perkins et al. Clin Pharmacol Ther. 2011 Mar.

Abstract

Initial screening of medications for efficacy in treating drug dependence may be accomplished more efficiently by using novel approaches that combine the practical advantages of within-subject laboratory studies with the clinical validity provided by clinical trials. A priori selection of functional gene variants associated with the pharmacokinetic or pharmacodynamic effects of a medication may aid this effort by controlling for individual variability as to clinical response or adverse effects; however, there are limitations to this approach, and these should be carefully considered.

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Conflict of interest statement

Conflict of Interest

K.A.P. has served as a consultant for Cypress Bioscience. C.L. has served as a consultant for and received research funding from AstraZeneca, GlaxoSmithKline, and Pfizer.

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