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Review
. 2011 Feb;30(2):114-9.
doi: 10.5732/cjc.010.10377.

The prevalence and prevention of nasopharyngeal carcinoma in China

Su-Mei Cao  1 , Malcolm J Simons, Chao-Nan Qian
Affiliations
Review

The prevalence and prevention of nasopharyngeal carcinoma in China

Su-Mei Cao et al. Chin J Cancer. 2011 Feb.

Abstract

Nasopharyngeal carcinoma (NPC) has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970's, high-risk populations in southern China have been screened extensively for early detection of NPC using anti-Epstein-Barr virus (EBV) serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening.

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Figures

Figure. 1
Figure. 1. The cancer mortality distribution map in China plotted by the Chinese death survey results in 1979. The numbers at the top of figure are values per 100 000 person-years. This figure was previously published and is cited from reference with permission.
See this image and copyright information in PMC

References

    1. Jia WH, Huang QH, Liao J, et al. Trends in incidence and mortality of nasopharyngeal carcinoma over a 20–25 year period (1978/1983–2002) in Sihui and Cangwu counties in southern China [J] BMC Cancer. 2006;6:178–186. - PMC - PubMed
    1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [J] CA Cancer J Clin. 2005;55(2):74–108. - PubMed
    1. Min HQ. The time trends of nasopharyngeal carcinoma: incidence rate and mortality for 20 years [M] In: Min HQ, editor. Study of nasopharyngeal carcinoma. Guangzhou: Science and Technology Press; 1998. pp. 6–12. [in Chinese]
    1. Zhang SW, Chen WQ, Kong LZ, et al. An annual report: cancer incidence in 35 cancer registries in China, 2003 [J] Bull of Chin Cancer. 2007;16(7):494–506. [in Chinese]
    1. Cancer Research Office of Ministry of Health . Beijing: People's Medical Publishing House; 1979. Investigation of cancer mortality in China [M] pp. 224–249. [in Chinese]