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Review
. 1990 Dec;11(12):443-9.
doi: 10.1016/0167-5699(90)90173-7.

Biological and clinical aspects of interleukin 6

T Hirano  1 , S Akira, T Taga, T Kishimoto
Affiliations
Review

Biological and clinical aspects of interleukin 6

T Hirano et al. Immunol Today. 1990 Dec.

Abstract

Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

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Comment in

  • Further functions of IL-6.
    Hopkins SJ, Rothwell NJ. Hopkins SJ, et al. Immunol Today. 1991 May;12(5):170. doi: 10.1016/S0167-5699(05)80050-7. Immunol Today. 1991. PMID: 1750926 No abstract available.

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