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Review
. 2011:2011:790132.
doi: 10.1155/2011/790132. Epub 2011 Jan 2.

Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases

Maria G Barderas  1 , Carlos M Laborde, Maria Posada, Fernando de la Cuesta, Irene Zubiri, Fernando Vivanco, Gloria Alvarez-Llamas
Affiliations
Review

Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases

Maria G Barderas et al. J Biomed Biotechnol. 2011.

Abstract

Metabolomics involves the identification and quantification of metabolites present in a biological system. Three different approaches can be used: metabolomic fingerprinting, metabolic profiling, and metabolic footprinting, in order to evaluate the clinical course of a disease, patient recovery, changes in response to surgical intervention or pharmacological treatment, as well as other associated features. Characteristic patterns of metabolites can be revealed that broaden our understanding of a particular disorder. In the present paper, common strategies and analytical techniques used in metabolomic studies are reviewed, particularly with reference to the cardiovascular field.

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Figures

Figure 1
Figure 1
Suitability of gas and liquid chromatography for metabolomic analysis based on metabolite polarity. Courtesy of Agilent Technologies [53].
Figure 2
Figure 2
Schematic view of the sample pretreatment for metabolomic analysis of frozen tissue or biological fluid prior to GC-MS or LC-MS analysis.
Figure 3
Figure 3
Common strategies in metabolomics: fingerprinting, profiling and footprinting.
See this image and copyright information in PMC

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