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Review
. 2010;2(3):95-9.
doi: 10.4274/jcrpe.v2i3.95. Epub 2010 Aug 1.

Update on some aspects of neonatal thyroid disease

Tamar Simpser  1 , Robert Rapaport
Affiliations
Review

Update on some aspects of neonatal thyroid disease

Tamar Simpser et al. J Clin Res Pediatr Endocrinol. 2010.

Abstract

This article explores the basic development and pathophysiology of the thyroid gland. New factors in the normal development of the thyroid in the neonate are mentioned. The incidence of congenital hypothyroidism continues to increase. We describe congenital hypothyroidism, its possible etiologies, treatment and outcomes. We explore hypothyroxinanemia in pre-term neonates and the risk/benefit of prophylactic thyroid hormone replacement. We discuss the late rise of thyrotropin (TSH) in ill infants and those with very low birth weight. Ill infants or those born premature should have their thyroid function tests routinely monitored. On the occasion of borderline thyroid function test results, TRH testing can be useful in identifying those infants with either persistent or transient hypothyroidism. TRH testing is also helpful in identifying those patients with secondary hypothyroidism. With the early identification and prompt and proper treatment, neonates with congenital hypothyroidism, transient or persistent, should have positive long-term outcomes.

Keywords: congenital hypothyroidism; thyroxine.

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References

    1. Langer P. History of goiter. In: Endemic Goitre., editor. WHO Monograph Series. Geneva: 1960. pp. 9–25. - PubMed
    1. Merke F. The History of Endemic Goitre and Cretinism in the Thirteenth to Fifteenth Centuries. Proc R Soc Med. 1960;53:995–1002. - PMC - PubMed
    1. Montanelli L, Tonacchera M. Genetics and phenomics of hypothyroidism and thyroid dys− and agenesis due to PAX8 and TTF1 mutations. Mol Cell Endocrinol. 2010;30:64–71. - PubMed
    1. Tonacchera M, Banco M.E., Montanelli L, Di Cosmo C, Agretti P, De Marco G, Ferrarini E, Ordookhani A, Perri A, Chiovato L, Santini F, Vitti P, Pinchera A. Genetic analysis of the PAX8 gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variant. Clin Endocrinol (Oxf) 2007;67:34–40. - PubMed
    1. Iwatani N, Mabe H, Devriendt K, Kodama M, Miike T. Deletion of NKX2−1 gene encoding thyroid transcription factor−1 in two siblings with hypothyroidism and respiratory failure. J Pediatr. 2000;137:272–276. - PubMed