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. 1978 Sep;75(9):4306-9.
doi: 10.1073/pnas.75.9.4306.

Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands

C H Li, D Chung, D Yamashiro, C Y Lee

Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands

C H Li et al. Proc Natl Acad Sci U S A. 1978 Sep.

Abstract

A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.

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References

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