Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Feb;53(2):718-9.
doi: 10.1002/hep.23940. Epub 2010 Dec 17.

No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

Hartmut Jaeschke, C David Williams, Anwar Farhood
Comment

No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

Hartmut Jaeschke et al. Hepatology. 2011 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Fasted C57BL/6 mice were treated with 300 mg/kg APAP in saline for 6 h (A,C) or 700 mg/kg galactosamine/100μg/kg endotoxin for 5 h (B,D). Tissue sections were stained with hematoxylin and eosin (H&E) (A,B) or with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) (C,D). H&E sections (x200) and inserts (x400) show necrotic cells with vacuolization, cell swelling and nuclear disintegration after APAP overdose (black arrows). Sections of Gal/ET-treated mice show nuclear condensation, cell shrinkage and formation of apoptotic bodies all consistent with apoptosis (white arrows). TUNEL staining shows APAP-induced release of nuclear DNA into the cytoplasm and eventually extracellular space as indicated by diffuse staining in the area of necrosis (C) while Gal/ET-induced apoptosis causes only distinct nuclear staining (D).
See this image and copyright information in PMC

Comment on

References

    1. Hu B, Colletti LM. CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity. Hepatology. 2010;52:691–702. - PMC - PubMed
    1. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. 2003;125:1246–1257. - PubMed
    1. Gujral JS, Knight TR, Farhood A, Bajt ML, Jaeschke H. Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci. 2002;67:322–328. - PubMed
    1. Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther. 2005;315:879–887. - PubMed
    1. Jaeschke H, Cover C, Bajt ML. Role of caspases in acetaminophen-induced liver injury. Life Sci. 2006;78:1670–1676. - PubMed