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. 1990 Nov;6(11):1247-50.
doi: 10.1089/aid.1990.6.1247.

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees

E A Emini  1 , W A Schleif, J C Quintero, P G Conard, J W Eichberg, G P Vlasuk, E D Lehman, M A Polokoff, T F Schaeffer, L D Schultz, et al.
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Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees

E A Emini et al. AIDS Res Hum Retroviruses. 1990 Nov.

Abstract

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.

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