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Review
. 2011 May;13(5):502-15.
doi: 10.1016/j.micinf.2011.01.014. Epub 2011 Jan 27.

The contribution of animal models to the understanding of the host range and virulence of influenza A viruses

Christopher D O'Donnell  1 , Kanta Subbarao
Affiliations
Review

The contribution of animal models to the understanding of the host range and virulence of influenza A viruses

Christopher D O'Donnell et al. Microbes Infect. 2011 May.

Abstract

Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research. The following review discusses the contribution of mice, ferrets, and non-human primates to the study of influenza virus host range and pathogenicity.

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References

    1. Belser JA, Szretter KJ, Katz JM, Tumpey TM. Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. Adv Virus Res. 2009;73:55–97. - PubMed
    1. Barnard DL. Animal models for the study of influenza pathogenesis and therapy. Antiviral Res. 2009;82:A110–22. - PMC - PubMed
    1. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O’Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med. 2001;7:1306–1312. - PubMed
    1. Centers for Disease Control and Prevention. Prevention and control of influenza with vaccines- recommendations of the Advisory Committee on Immunization Practices (ACIP), (2010) MMWR. 2010;59:RR08:1–62. - PubMed
    1. Beare AS, Webster RG. Replication of avian influenza viruses in humans. Arch Virol. 1991;119:37–42. - PubMed

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