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Meta-Analysis
. 2011 Mar;43(3):185-7.
doi: 10.1038/ng.760. Epub 2011 Jan 30.

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Sara Lindström  1 , Celine M Vachon, Jingmei Li, Jajini Varghese, Deborah Thompson, Ruth Warren, Judith Brown, Jean Leyland, Tina Audley, Nicholas J Wareham, Ruth J F Loos, Andrew D Paterson, Johanna Rommens, Darryl Waggott, Lisa J Martin, Christopher G Scott, V Shane Pankratz, Susan E Hankinson, Aditi Hazra, David J Hunter, John L Hopper, Melissa C Southey, Stephen J Chanock, Isabel dos Santos Silva, JianJun Liu, Louise Eriksson, Fergus J Couch, Jennifer Stone, Carmel Apicella, Kamila Czene, Peter Kraft, Per Hall, Douglas F Easton, Norman F Boyd, Rulla M Tamimi
Affiliations
Meta-Analysis

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Sara Lindström et al. Nat Genet. 2011 Mar.

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

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Figures

Figure 1
Figure 1
Regional association plot for ZNF365 across a 300kb window. Association of individual SNPs is plotted as –log10(P) against chromosomal base-pair position. Results of both genotyped and imputed SNPs are provided. Colors indicate the LD relationship between rs10995190 and the other markers (red, r2>0.8). The right-hand Y axis shows the recombination rate estimated from the HapMap CEU population. All p-values are from the discovery phase.
See this image and copyright information in PMC

References

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