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Comment
. 2011 May 19;30(20):2304-6.
doi: 10.1038/onc.2010.641. Epub 2011 Jan 31.

Commentary. A picture of Mitf in melanoma immortality

C R Goding  1
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Comment

Commentary. A picture of Mitf in melanoma immortality

C R Goding. Oncogene. .

Abstract

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.

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