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. 2011 Feb 25;74(2):185-93.
doi: 10.1021/np100613p. Epub 2011 Jan 31.

Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa

Zhenyu Lu  1 , Ryan M Van Wagoner, Mary Kay Harper, Heather L Baker, John N A Hooper, Carole A Bewley, Chris M Ireland
Affiliations

Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa

Zhenyu Lu et al. J Nat Prod. .

Abstract

Four new depsipeptides, mirabamides E-H (1-4), and the known depsipeptide mirabamide C (5) have been isolated from the sponge Stelletta clavosa, collected from the Torres Strait. The planar structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The absolute configurations were established by the advanced Marfey's method, NMR, and GC-MS. The four new compounds all showed strong inhibition of HIV-1 in a neutralization assay with IC(50) values of 121, 62, 68, and 41 nM, respectively.

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Figures

Figure 1
Figure 1
TOCSY and key HMBC and NOESY correlations for compound 1.
Figure 2
Figure 2
Effects of mirabamides E-H in HIV-1 neutralization assays (standard deviations averaged 15%).
See this image and copyright information in PMC

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