Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Feb;178(2):485-9.
doi: 10.1016/j.ajpath.2010.10.038.

TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation

Ambra Pozzi  1 , Roy Zent
Affiliations
Comment

TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation

Ambra Pozzi et al. Am J Pathol. 2011 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of integrin αvβ8–mediated TGF-β activation in nonglomerular (A) and glomerular (B and C) cells. A: In nonglomerular cells, integrin αvβ8–bound latent TGF-β is normally activated by MT1-MMP. B: In contrast, in the glomerulus of the kidney, lack of MT1-MMP expression by mesangial cells prevents integrin αvβ8–mediated TGF-β activation. C: Deletion of the integrin β8 subunits results in increased release of activated TGF-β by mesangial cells, which modulates glomerular endothelial cell apoptosis. RGD, arginine–glycine–aspartic acid.
See this image and copyright information in PMC

Comment on

References

    1. Khan S L.-R.S., McCarty J.H., Sorenson C.M., Sheibani N., Reichardt L.R., Kim J.H., Wang B., Sedor J.R., Shelling J.R. Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1. Am J Pathol. 2011;178:609–620. - PMC - PubMed
    1. Askari J.A., Buckley P.A., Mould A.P., Humphries M.J. Linking integrin conformation to function. J Cell Sci. 2009;122:165–170. - PMC - PubMed
    1. Kreidberg J., Donovan M., Goldstein S., Rennke H., Shepherd K., Jones R., Jaenisch R. α 3 β 1 integrin has a crucial role in kidney and lung organogenesis. Development. 1996;122:3537–3547. - PubMed
    1. Sachs N., Kreft M., van den Bergh Weerman M.A., Beynon A.J., Peters T.A., Weening J.J., Sonnenberg A. Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006;175:33–39. - PMC - PubMed
    1. Pozzi A., Jarad G., Moeckel G.W., Coffa S., Zhang X., Gewin L., Eremina V., Hudson B.G., Borza D.B., Harris R.C., Holzman L.B., Phillips C.L., Fassler R., Quaggin S.E., Miner J.H., Zent R. β1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol. 2008;316:288–301. - PMC - PubMed

Publication types

MeSH terms

Substances