Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2011 Mar;94(1-2):117-20.
doi: 10.1016/j.eplepsyres.2011.01.007. Epub 2011 Feb 1.

Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy

Priscila Freitas-Lima  1 , Veriano Alexandre Jr, Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, Americo Ceiki Sakamoto
Affiliations
Clinical Trial

Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy

Priscila Freitas-Lima et al. Epilepsy Res. 2011 Mar.

Abstract

To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.

PubMed Disclaimer

Publication types

MeSH terms