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Review
. 2011 Feb;26(1):10-28.
doi: 10.1177/1533317510390351.

Risk of cerebrovascular adverse events and death in elderly patients with dementia when treated with antipsychotic medications: a literature review of evidence

Vikrant Mittal  1 , Lekshminarayana Kurup, Deena Williamson, Sunanda Muralee, Rajesh R Tampi
Affiliations
Review

Risk of cerebrovascular adverse events and death in elderly patients with dementia when treated with antipsychotic medications: a literature review of evidence

Vikrant Mittal et al. Am J Alzheimers Dis Other Demen. 2011 Feb.

Abstract

Behavioral and Psychological Symptoms of Dementia (BPSD) are increasingly recognized as a major risk factor for caregiver burden, institutionalization, greater impairment in activities of daily living (ADLs), more rapid cognitive decline, and a poorer quality of life. BPSD contribute significantly to the direct and indirect costs of caring for patients with dementia even after adjusting for the severity of cognitive impairment and other co-morbidities. Research on these symptoms has indicated a complex interplay between the biological, psychological and social factors involved in the disease process. Although some psychotropic medications have shown modest efficacy in the treatment of these behaviors, their use has generated controversy due to increasing recognition of the side effects of these medications especially the antipsychotic medications. In this review, we examine the risk of cerebrovascular adverse events (CVAEs) and death with antipsychotic medications when used to treat elderly patients with dementia.

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References

    1. Devanand DP, Jacobs DM, Tang MX, et al. The course of psychopathologic features in mild to moderate Alzheimer disease. Arch Gen Psychiatry. 1997. ;54(3):257-263. - PubMed
    1. Jeste DV, Finkel SI Psychosis of Alzheimer’s disease and related dementias: diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry . 2000;8(1):29-34. - PubMed
    1. Paulsen JS, Salmon DP, Thal LJ, et al. Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology. 2000. ;54(10):1965-1971. - PubMed
    1. Bharucha AJ, Rosen J., Mulsant BH, Pollock BG Assessment of behavioral and psychological symptoms of dementia. CNS Spectr. 2002;7(11):797-802. - PubMed
    1. Lawlor B. Managing behavioural and psychological symptoms of dementia. Br J Psychiatry. 2002;181(6):463-465. - PubMed

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