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. 2011 May;55(5):2431-3.
doi: 10.1128/AAC.01587-10. Epub 2011 Jan 31.

Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children

J Chase McNeil  1 , Kristina G Hulten, Sheldon L Kaplan, Edward O Mason
Affiliations

Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children

J Chase McNeil et al. Antimicrob Agents Chemother. 2011 May.

Abstract

Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P=0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.

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References

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