Activity of ACHN-490 tested alone and in combination with other agents against Pseudomonas aeruginosa

Abstract

ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h.

Fig. 1.

Graphic illustration of the synergy at subinhibitory concentrations of ACHN-490 when combined with each antimicrobial tested for P. aeruginosa strain 385. Abbreviations: CEF, cefepime; DOR, doripenem; IMP, imipenem; P/T, piperacillin-tazobactam.