Mutation: the perils of transcription

Comment

Mary Muers. Nat Rev Genet. 2011 Mar.

. 2011 Mar;12(3):156.

doi: 10.1038/nrg2960. Epub 2011 Feb 1.

No abstract available

Comment on

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.
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Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.
Takahashi DT, Burguiere-Slezak G, Van der Kemp PA, Boiteux S. Takahashi DT, et al. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):692-7. doi: 10.1073/pnas.1012582108. Epub 2010 Dec 21. Proc Natl Acad Sci U S A. 2011. PMID: 21177431 Free PMC article.
Yeast Sen1 helicase protects the genome from transcription-associated instability.
Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. Mischo HE, et al. Mol Cell. 2011 Jan 7;41(1):21-32. doi: 10.1016/j.molcel.2010.12.007. Mol Cell. 2011. PMID: 21211720 Free PMC article.