RNA seeds nuclear bodies
- PMID: 21283118
- DOI: 10.1038/ncb0211-110
RNA seeds nuclear bodies
Abstract
The interior of the eukaryotic cell nucleus is populated by a multitude of microscopic domains termed nuclear bodies. Despite having attracted much attention, how these compartments form and are maintained remained elusive. Now, two live-cell imaging studies provide compelling evidence that nascent RNAs can act as transiently immobilized scaffolds that recruit specific nuclear body proteins.
Comment on
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Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.Nat Cell Biol. 2011 Jan;13(1):95-101. doi: 10.1038/ncb2140. Epub 2010 Dec 19. Nat Cell Biol. 2011. PMID: 21170033 Free PMC article.
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Nucleation of nuclear bodies by RNA.Nat Cell Biol. 2011 Feb;13(2):167-73. doi: 10.1038/ncb2157. Epub 2011 Jan 16. Nat Cell Biol. 2011. PMID: 21240286
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