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Comment
. 2011 Feb;13(2):112-4.
doi: 10.1038/ncb0211-112.

Proclaiming fate in the early mouse embryo

Magdalena Zernicka-Goetz  1
Affiliations
Comment

Proclaiming fate in the early mouse embryo

Magdalena Zernicka-Goetz. Nat Cell Biol. 2011 Feb.

Abstract

In the mouse embryo, the first differences between cells that result in distinct lineages have long been thought to arise only as a consequence of differential cell positioning at relatively late preimplantation stages. Differences in Oct4 transcription factor kinetics between cells at the 4-8-cell stage are now shown to be predictive of future lineages, providing further evidence for much earlier initiation of cell fate decisions.

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References

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