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. 2011 Apr;21(4):558-60.
doi: 10.1038/cr.2011.20. Epub 2011 Feb 1.

Mitochondrial ROS fuel the inflammasome

Matthew T Sorbara  1 , Stephen E Girardin
Affiliations

Mitochondrial ROS fuel the inflammasome

Matthew T Sorbara et al. Cell Res. 2011 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Mitochondrial ROS promote NLRP3 inflammasome formation. Treatment of macrophages with MSU, alum or nigericin leads to the production of mitochondrial ROS. In (1), this triggers the induction of mitophagy and the formation of an LC3+ autophagosome to remove the damaged mitochondria. In (2), the induction of mitochondrial ROS induces the recruitment of NLRP3 to MAMs. NLRP3 recruits ASC through PYD-PYD interaction (shown in dark blue), which then recruits pro-caspase-1 through CARD-CARD interactions (shown in yellow). This results in the activation of caspase-1 and the production of IL-1β.
See this image and copyright information in PMC

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