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. 1990 Dec;54(4):473-7.
doi: 10.1254/jjp.54.473.

Glibenclamide specifically blocks ATP-sensitive K+ channel current in atrial myocytes of guinea pig heart

E Hamada  1 , R Takikawa, H Ito, M Iguchi, A Terano, T Sugimoto, Y Kurachi
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Free article

Glibenclamide specifically blocks ATP-sensitive K+ channel current in atrial myocytes of guinea pig heart

E Hamada et al. Jpn J Pharmacol. 1990 Dec.
Free article

Abstract

Effects of glibenclamide on the control membrane ionic currents, acetylcholine or adenosine-induced K+ current, and nicorandil-induced K+ current were examined in single atrial myocytes of guinea pig heart. The nystatin-whole cell clamp technique was used. Nicorandil evoked the time-independent K+ current which is probably the current through the ATP-sensitive K+ channel. Glibenclamide inhibited this current in a concentration-dependent fashion, although it had no effect on the other currents. We concluded that glibenclamide specifically inhibits the ATP-sensitive K+ channel current in cardiac myocytes.

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